Faculty and Staff

CAROL BAGNELL, Ph.D.

Education:

1970-1974 - B.A., Biology, Glassboro State College, Glassboro, New Jersey
1974-1976 - M.S., Biology, West Virginia University, Morgantown, WV
1978-1983 - Ph.D., Endocrinology, Medical College of Georgia, Augusta, GA

Positions Held:

2008-present - Chair, Dept of Animal Sciences, Rutgers University, New Brunswick, NJ
2002-present - Professor, Dept. of Animal Sciences, Rutgers, the State University of New Jersey
2001-2002 - Sabbatical, Endocrinology Discovery Group, Merck Research Laboratories, Rahway, NJ
1995-1999 - Associate Chair, Dept. of Animal Sciences, Rutgers, the State University of New Jersey
1994-present - Associate Professor, Dept. of Animal Sciences, Rutgers, the State University of New Jersey
1988-1994 - Assistant Professor, Dept. of Animal Sciences, Rutgers, the State University of New Jersey
1988-1989 - Visiting Scientist, Reproduction Research Branch, NICHD, NIH
1987-1988 - Associate Researcher, Pacific Biomedical Research Center, University of Hawaii, Honolulu
1985-1986 - Assistant Researcher, Pacific Biomedical Research Center, University of Hawaii, Honolulu
1983-1984 - Postdoctoral Fellow, Anatomy and Reproductive Biology, University of Hawaii, Honolulu

Awards:

2008 – Relaxin 2008 – 5th International Conference on Relaxin and Relaxin-Related Peptides, Organizing Committee Member
2004 – Graduate Program Award, Dept of Animal Sciences, Rutgers University, New Brunswick, NJ
2003 – Distinguished Alumna Award, Medical College of Georgia School of Graduate Studies, Augusta, Georgia
2002 – 4^th International Conference on Relaxin and Relaxin-Related Peptides, Organizing Committee member
2002-present – Editorial Board, Reproductive Biology and Endocrinology
2000 - Member, Grant Review Panel-USDA Animal Reproductive Efficiency
1993 - NIH-Biochemical Endocrinology Study Section, ad hoc member
1992 - NIH Special Study Section, Small Business Innovation Research, ad hoc member 1990-1999 - Reviewer, U.S. Dept. of Agriculture, NATO, and BARD proposals

Selected Publications:

Bagnell CA, Steinetz BG, Bartol FF. 2008. Milk-borne relaxin and the lactocrine hypothesis for maternal programming of neonatal tissues. Ann N Y Acad Sci. (in press)
Ryan PL, Christiansen DL, Hopper RM, Bagnell CA, Vaala WE, LeBlanc MM. 2008. Evaluation of systemic relaxin blood profiles in horses as a means of assessing placental function in high-risk pregnancies and responsiveness to therapeutic strategies. Ann NY Acad Sci (in press).
Yan W, Chen J, Wiley AA, Bartol FF, Bagnell CA. 2008. Relaxin and estrogen affect estrogen receptor alpha, vascular endothelial growth factor and relaxin receptor expression in the neonatal porcine uterus and cervix. Reproduction 135:705-712.
Santora K, Rasa C, Visco D, Steinetz BG, Bagnell CA. 2007. Antiarthritic effects of relaxin, in combination with estrogen, in rat adjuvant-induced arthritis. J Pharmacol & Experimental Therapeutics Aug 322(2): 887-893.
Ho TY, Yan W, Bagnell CA. 2007. Relaxin-induced matrix metalloproteinase-9 expression is associated with the activation of the NF-kB pathway in human THP-1 cells. J Leukocyte Biology 81:1303-1310.
Lamprecht E D, Bagnell CA, Williams CA. 2007. Inflammatory responses to three modes of intense exercise in Standardbred mares. Equine Sci. Soc. Proc. 20: 76-77.
Yan W, Wiley AA, Bathgate RAD, Frankshun AL, Lasano S, Crean BD, Steinetz BG, Bagnell CA, Bartol FF. 2006. Expression of LGR7 and LGR8 by neonatal porcine uterine tissues and transmission of milk-borne relaxin into the neonatal circulation by suckling. Endocrinology 147:4303-10.
Neumann J, Lazaris A, Huang YJ, Karatzas C, Ryan R, Bagnell CA. 2005. Production and characterization of recombinant equine prorelaxin. Domestic Animal Endocrinology 31:173-185.
Ryan, P.L., K. Bennett-Wimbush, W.E. Vaala, and C.A. Bagnell. 2002. Relaxin and placental dysfunction in the horse. In Relaxin 2000 ed. By G.W. Tregear, R. Ivell, R.A. Bathgate, and J.D. Wade, Kluwer Scientific Publishers, Netherlands, pp. 91-99.
Lenhart, J.A., P.L. Ryan, K.M. Ohleth, S.S. Palmer, and C.A. Bagnell. 2002. Relaxin increases secretion of matrix metalloproteinase-2 and -9 during uterine and cervical growth and remodeling in the pig. Endocrinology 143:91-98.
Neumann, J., Y-J. Huang, P.L. Ryan, and C.A. Bagnell. 2001. Production and characterization of recombinant equine relaxin. Biol Reprod 64(1): 599.
Ryan, P.L., D.L. Baum, J.A. Lenhart, K.M. Ohleth, and C.A. Bagnell. 2001. Uterine and cervical epithelial cadherin expression during relaxin-induced growth. Reproduction 122:929-937.
Ryan, P.L., K. Bennett-Wimbush, W.E. Vaala, and C.A. Bagnell. 2001. Systemic relaxin in pregnant pony mares grazed on endophyte infected fescue: Effects of fluphenazine treatment. Theriogenology 56:471-483.
Kirkup, K, A. Mallin, and C.A. Bagnell. 2000. Inhibition of porcine granulosa cell adhesion and growth in vitro by immunoneutralization of epithelial cadherin. J Reprod & Fertility 120:275-281.
Ryan, P.L., K. Bennet-Wimbush, W. Vaala, and C.A. Bagnell. 1999. Relaxin as a biochemical marker of placental insufficiency in the horse: a review. Pferdeheilkunde (Equine Health) 15:622-626.
Lenhart, J.A., P.L. Ryan, K.M. Ohleth, and C.A. Bagnell. 1999. Expression of connexin-26,-32 and -43 gap junction proteins in the porcine cervix and uterus during pregnancy and relaxin-induced growth. Biol Reprod 61:1452-1459.
Ohleth, K.M., Q. Zhang, J.A. Lenhart, P.L. Ryan, and C.A. Bagnell. 1999. Trophic effects of relaxin on reproductive tissue: Role of the IGF system. Steroids 64: 634-639.
Ohleth, K.M. and C.A. Bagnell. 1999. Relaxin secretion and gene expression in porcine granulosa and theca cells are stimulated during in vitro luteinization. Biol Reprod 60:499-507.
Wang-Lee, J.L., J.A. Lenhart, K.M. Ohleth, P.L. Ryan, and C.A. Bagnell. 1998. Regulation of urokinase-and tissue-type plasminogen activator by relaxin in the uterus and cervix of the prepubertal gilt. J Reprod Fertility 114: 119-125.
Ohleth, K.M., Q. Zhang, and C.A. Bagnell. 1998. Relaxin protein and gene expression in ovarian follicles of immature pigs. J Molecular Endocrinology 21:179-187.
Ryan, P., K. Bennet-Wimbush, W. Loch , W. Vaala, and C.A. Bagnell. 1998. Effects of fescue toxicosis and fluphenazine on relaxin concentrations in pregnant pony mares. American Association of Equine Practitioners Proceedings 44: 60-61.
Ryan, P., W.Vaala, and C.A. Bagnell. 1998. Evidence that equine relaxin is a good indicator of placental insufficiency in the mare. American Assoc. of Equine Practitioners Proceedings 44:62-63.

Contact:

Carol Bagnell, Ph.D.
Professor and Chair
Department of Animal Sciences, Foran Hall 126
School of Environmental and Biological Sciences

Rutgers, the State University of New Jersey
59 Dudley Road
New Brunswick, NJ 08901-8525
732-932-8165 x 102 (T)
732-932-6996 (F)
bagnell@aesop.rutgers.edu